Context - Objective: The aim of this study is to assess the differences between overweight (OW) and obese (OB) adolescents with (BN+) or without (BN-) Bulimia Nervosa regarding menstrual patterns, Sex Hormone-Binding Globulin (SHBG), Testosterone (T), Free Androgen Index (FAI), Insulin and ovarian ultrasonographic (U/S) characteristics. Methods - Patient(s) - Intervention(s): Prospective study of 32 BN+ compared to 67 BN- OW & OB adolescents matched for age, BMI, WHR and Waist Circumference. Menstrual patterns were recorded, SHBG, T, FAI, glucose and Insulin were measured, while ovarian U/S characteristics were assessed in all girls. Main Outcome Measure(s) - Result(s): 21/32 BN+ and 26/67 BN- girls reported oligomenorrhea, amenorrhoea or polymenorrhea (65,6% vs 38,8%, p=0.012). Mean fasting Insulin levels (27.32 vs 22.74 mIU/L), mean fasting Glucose levels (107.7 vs 96.16 mg/dl) mean serum T levels (1.46 vs 1.12 ng/ml), mean FAI (7.6 vs 4.6) and mean SHBG (66.65 vs 84.34 nmol/l) where significantly different in BN+ compared to BN- OW and OB adolescents (all p < 0.05). There was no significant difference in U/S ovarian characteristics between the two Groups. Conclusions: BN+ OW and OB adolescents, independently of body weight or fat distribution, are in greater risk to present menstrual disorders, fasting glucose and Insulin disorders, as well as hyperandrogenemia compared to controls. A multidisciplinary approach is always indicated for these patients with a seriously unhealthy hormonal and metabolic profile, while further studies, with greater sample are needed to confirm these results.