Objective: the search of molecular genetic markers in endometrial tissue of reproductive age women with intrauterine adhesions comparув to the endometrium of healthy women. Methods: clinical and laboratory examination, pipel-biopsy, surgical treatment, microarray transcriptome analysis (Affymetrix GeneChip Human Exon 1.0 ST). Patient(s): group 1 – patients with intrauterine adhesions (n=10), group 2 – healthy women without intrauterine adhesions (n=10). Intervention(s): surgical treatment of 20 women of reproductive age – hysteroscopic adhesiolysis in the middle stage of proliferation phase of menstrual cycle (9th day of the menstrual cycle). Main Outcome Measure(s): we found 10 genes with expression level changed 3 times and more in endometrial tissues of women with intrauterine adhesions compared to the endometrial tissues of women of group of conditionally healthy women, of which 9 genes show increased expression on case of intrauterine adhesions (S100A8, HBB, VNN2, RGS2, ERAP2, AQP9, MNDA, TUBA3E, FCGR3B) and 1 – decreased expression (NTRK3). Result(s): expression of genes S100A8, HBB, VNN2, RGS2, ERAP2, AQP9, MNDA, TUBA3E, FSGR3B is increased in endometrial tissues of women with intrauterine adhesions. Conclusion: the found differences in gene expression levels in endometrial tissues of women with intrauterine adhesions may be helpful in either study of the pathogenesis of the lesion or in designing a molecular diagnostic tool used to individualize the treatment of the lesion.