Context: Ovarian cancer is the second most common gynecologic malignancy and the most common cause of death from gynecologic cancers. It is the fifth cause of death in all women worldwide. Some of the parameters from complete blood count (CBC) have been suggested for use in the diagnosis and prediction of the prognosis of ovarian cancer, however, data from different studies are conflicting. Objective: To detect the value of lymphocytic count, platelet count as well as platelet/lymphocyte ratio (PLR) from complete blood count (CBC) panel in epithelial ovarian cancer. Patients and methods: This study has been conducted on 36 cases having epithelial ovarian malignancy presented to the Gynecologic Oncology Unit of Elshatby University Hospital. Assessment of platelet count, lymphocyte count and PLR from the preoperative CBC of all patients and their values were correlated with the tumor type, grade, stage of the disease and CA125 level. Results: Platelet count ranged between 174 – 700 (x103) / mcL with a mean of 371.39 ± 108.093 (x103) while lymphocytic count ranged between 0.22 – 10.03 (x103) cells/mcL with a mean of 2.447 ± 1.683 (x103) and PLR ranged between 1.468 – 401.9 with a mean of 176.87 ± 81.366. There was a statistically significant difference of PLR between the different stages (P=0.007), while there was no statistically significant difference with tumor grade and type (P=0.770, P=0.771 respectively). A positive correlation existed between PLR and CA125 (r=0.184, p < 0.05). Conclusion: Platelet to lymphocyte ratio significantly increases with advancing stages of epithelial ovarian cancer and it is positively correlated with CA125. Key words: Platelet to lymphocyte ratio; Epithelial ovarian cancer, CA125.