Poster Session
Pasman N.M., Chumanova O.V., Voronina E.N., Philipenko M.L., Drobinskaya A.N. Assessment of a role of hemostasis system genes polymorphism and the genes which are responsible for formation of an endothelium dysfunction in development of gestational complications The strength of association between polymorphisms of hemostasis system and endothelium dysfunction genes and development of gestational complications was assessed. The research included two groups of women: experimental (n=265) and control (n=192). The first group consisted of women with pregnancy pathology (preeclampsia, placental abruption, strong placental failure, syndrome of a fetus loss). The control group comprised women without pregnancy pathology who gave birth to a healthy child. Allele A of prothrombin G20210A mutation, allele C of locus G634C (gene VEGF), allele 4G of the polymorphic locus 5G/4G of gene PAI-1 were associated with risk of development of obstetric pathology (p < 0.05). Polymorphisms of MTHFR, еNOS, FV genes don't lead to development of gestational complications. Keywords: pregnancy complications, thrombophilia, endothelial dysfunction, polymorphism of genes.