Poster Session
Abstract Objective: The study was to detect the methylation level of SOX9 gene promoter in cervical cancer scrapings and to explore its clinical significance. Methods: Taqman-based real-time PCR assay was carried out to detect the methylation level of SOX9 gene promoter in 48 cervical cancer scrapings and 48normal controls. Results: The methylation score of SOX9 gene promoter in cervical cancer scrapings was significantly higher than that in normal controls, in cervical squamous cell carcinoma than in adenocarcinoma (p < 0.05). The methylation score of SOX9 gene promoter was positive correlated with tumor grade, lymph node metastasis and vessel infiltration (p < 0.05). Conclusions: SOX9 methylation may play a crucial role in the pathogenesis and progression of cervical cancer, and may provide a valuable biomarker in diagnosis, treatment and prognosis evaluation for cervical cancer. Keywords :Cervical cancer; SOX9; Methylation; Taqman probes