P287. Subclinical atherosclerosis and calcium metabolism in apparently healthy, non-diabetic postmenopausal women.

Eleni Armeni (GR), Kimon Stamatelopoulos (GR), Evangelia Karropoulou (GR), Paraskevi Pliatsika (GR), Nikolaos Tsoltos (GR), Demetrios Rizos (GR), Areti Augoulea (GR), Georgios Kaparos (GR), Andreas Alexandrou (GR), Irene Lambrinoudaki (GR)

[Armeni] 2nd Department of Obstetrics and Gynecology, Athens, [Stamatelopoulos] Department of Therapeutics, [Karropoulou] 2nd Department of Obstetrics and Gynecology, Athens, [Pliatsika] 2nd Department of Obstetrics and Gynecology, Athens, [Tsoltos] 2nd Department of Obstetrics and Gynecology, Athens, [Rizos] Hormonal and Biochemical Laboratory, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, [Augoulea] 2nd Department of Obstetrics and Gynecology, Athens, [Kaparos] Hormonal and Biochemical Laboratory, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, [Alexandrou] 2nd Department of Obstetrics and Gynecology, Athens, [Lambrinoudaki] 2nd Department of Obstetrics and Gynecology, Athens

Context: Disorders in mineral metabolism have been linked with cardiovascular events in patients with chronic kidney disease, in individuals with the metabolic syndrome as well as in the general population. Objective: This study aimed to investigate the association between indices of calcium metabolism and arterial stiffness in a sample of apparently healthy, non-diabetic postmenopausal women. Methods: This cross-sectional study explored the association between indices of bone metabolism and arterial stiffness, estimated using measures of carotid-femoral pulse wave velocity (PWV), in a sample of postmenopausal women with no documented cardiovascular disease or diabetes. Measures of PWV were used in a continuous as well as in a dichotomous fashion, using the median value of 8.5m/s as a cut-off. Patients: The study sample consisted of 433 apparently healthy, non-diabetic postmenopausal women Interventions: Fasting venous blood samples were obtained for evaluation of calcium (Ca), phosphorus (P), magnesium (Mg), parathormone (PTH) and 25-hydroxyvitamin D levels, calcium-phosphorus (Ca-P) product. Ultrasonography was used to evaluate measures of the and PVW. Main outcome measures: 1) Link between PWV measures and indices of calcium metabolism; 2) Difference among indices of calcium metabolism in women with PWV higher or lower than the median PWV-value Results: The mean age of the participants was 56.7±4years. The readings of PWV correlated negatively with levels of phosphorus (r-coefficient=-0.122, p-value=0.023) as well as with the Ca-P product (r-coefficient=-0.126, p-value=0.021) and positively with PTH (r-coefficient=0.153, p-value=0.022). Moreover, phosphorus levels and the Ca-P product levels were lower in women with PWV>8.5m/s vs PWV≤8.5m/s [(3.45±0.46) mg/dl vs. (3.58±0.50) mg/dl, p-value=0.013 and (32.9±4.7) vs. (34.2±5.1), p-value=0.031 respectively). The inverse association between the Ca-P product and PWV remained significant after adjustment for age, years since menopause, systolic blood pressure, diastolic blood pressure, smoking and PTH. No other significant associations were observed between indices of calcium metabolism and PWV. Conclusion: Among ambulatory postmenopausal women, greater arterial stiffness indicated by higher PWV values associated with lower serum phosphorus levels and lower Ca-P product levels, even within the normal range. The clinical implications of our findings should be confirmed by larger prospective studies.