P247. Lower levels of serum vitamin D are in correlation with reduced ovarian reserve

Jelena Otasevic (RS), Mina Bozovic (RS), Ivana Rudic Biljic-Erski (RS), Mladenko Vasiljevic (RS)

[Otasevic] Poliklinika Park Medica, Belgrade, Serbia; GAK Narodni Front, Belgrade, [Bozovic] Poliklinika "Dr Dragoljub Mandic-Tedi", Belgrade, Serbia; GAK KCS, Belgrade, Serbia, [Rudic Biljic-Erski] GAK Narodni Front, Belgrade, Serbia, [Vasiljevic] GAK Narodni Front, Belgrade, Serbia; Faculty of Medicine, Belgrade, Serbia;

Context:There are many contradictory data about the correlation between lower levels of vitamin D and reduced ovarian reserve. It is known that vitamin D plays an important role in modulation of autoimmune response through its receptors in targeted tissues, such as ovarian. Anti-Mullerian hormone (AMH) is considered nowadays as an independent and reliable bio-marker of ovarian reserve, as it is secreted from the recruited antral ovarian follicles. Is there an important protective role of vitamin D in ovarian reserve, future large trials are to investigate. The objective was to find the correlation between levels of serum vitamin D with reduced ovarian reserve. Methods: In women with reduced ovarian reserve (inclusion criteria were serum level of AMH between 0,3 and 1.2 ng/ml, taken any day of menstrual cycle; normal ovarian volume and reduced antral follicle count), the levels of serum vitamin D have been measured. In statistical analysis, median value was calculated for each parameter due to the small sample for analysis. Spearman test was used for correlation. Patient(s): Ten women with median age 35 years (from 32 to 39 years) with reduced ovarian reserve (median AMH 0.77 ng/ml (0.6-1.18 ng/ml)), without family history of premature ovarian failure and without previous pregnancy were included. Intervention(s): Level of serum 25(OH)vitamin D was measured in included participants. The levels below 75 nmol/l have been considered as lower. Main Outcome Measure(s): Primary outcome was to find the correlation between reduced ovarian reserve (measured by level of serum AMH) and levels of serum vitamin D. Result(s): Median level of serum vitamin D was 47.99 mmol/l (range from 41.84 to 66 mmol/l). We have found that there was highly significant statistical correlation between levels of serum AMH and serum levels of vitamin D (rho=0.995, p < 0.01). Conclusions: High statistical correlation indicates that lower levels of serum vitamin D may play a role in reduced ovarian reserve. In perspective, the larger trial may come to more certain data about the correlation, as well as about the potential vitamin D role in the improvement of ovarian reserve.