Context: In the last three years, on a part of the territory of Eastern Ukraine, active combat operations have been carried out; they affected civilians in the region. According to the UNICEF data, about 60% of children from the war zone got psychological traumas. Objective: To estimate the state of gynecological health of female adolescents from the families of settlers from the war zone in the eastern regions of Ukraine. Methods: The study involved 20 female adolescents from the families of settlers into the Kharkiv region from the war zone. The work has been carried out at the Department of Obstetrics, Gynecology and Pediatric Gynecology of Kharkiv National Medical University (Head - Prof. Iryna Tuchkina). The all-round investigation comprised: general clinical and gynecological examination, ultrasonic scanning, hormonal profile, vaginoscopy, colposcopy, bacteriological tests, study of cancer markers and consultations of a pediatric surgeon, an urologist, a pediatrician. Results: It has been found that out of 20 female adolescents, 7 were diagnosed with abnormal pubertal uterine bleeding, 4 - with amenorrhea, 8 – with retention follicular оvarian cysts, 1 – with the anomaly of development of the internal reproductive organs. All female adolescents from the area of battle actions were tested for the level of stress. Examination of the female adolescent with the help of testing has registered a higher level of stress in the group with abnormal pubertal uterine bleeding and amenorrhea. This proves that any adverse factor, in this case stress, can trigger abnormal menstrual function in the period of physiological instability of the reproductive system functioning. Conclusions: The relationship between the hormonal state, simpatoadrenal system in puberty and stress influence has been proved, which confirms the important role of emotional stress in the pathogenesis of menstrual disorders.