Poster Session

P333. Breast cancer associated with pregnancy. Dobrokhotova J., Danielian S., Borovkova E. аnd Zalesskaya S. A.

Ekaterina Borovkova (RU)

[Borovkova] Pirogov RNIMU, Moscow

Pregnancy associated cancer –cancer which was detected during pregnancy, in the first year after birth or at any time in the breastfeeding. Patient A., 22 years old with a diagnosis of "26-27 weeks, pregnancy-associated breast cancer. Breast cancer stage IV. cT4bN3M1. Metastases to the ovary, lymph nodes in the neck on the right. Right-sided metastatic pleural effusion". In 9 weeks find a painless lump in the right breast. Conducted cor-biopsy. Histological examination confirmed invasive cancer of the right breast, special type, clear cell carcinoma glycogen-rich, grade 3, metastases in axillary lymph node and left ovary. Molecular biological subtype of metastatic breast carcinoma to the ovary. Baselinestudy triple negative type of tumor (Pgr-0 points, Her2-neu -0, Ki65-35%). Carried out 2 courses of polychemotherapy according to the scheme: doxorubicin 60 mg/m2 80 mg, cyclophosphamide 600 mg/m2 - 80 mg. Control breast ultrasound showed progression of disease, metastases in the left mammary gland, axial or supraclavicular lymph nodes on the left. Operation: laparotomy, cesarean section, bilateral adnexectomy, subtotal resection of omentum resection of the peritoneum. Intraoperatively: the left ovary presents cystic nodulated tumor, size 20х15х10 cm. The right ovary is similar macroscopic structure, size 6х4х4 sm. Histological study: the right ovary by the tumor tissue is built of cells with polymorphic nuclei anizohromii forming alveolar, trabecular structure and a solid field. Left ovary by the tumor tissue is built of cells with polymorphic nuclei anizohromii forming alveolar, trabecular structure and a solid field. The vessels are determined by tumor emboli.

 

 

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